alpha lipoic acid, neuropathy, neuropathy treatment

Unraveling the Pharmacokinetic Action of Alpha Lipoic Acid in Neuropathy Treatment

April 23, 20243 min read

Unraveling the Pharmacokinetic Action of Alpha Lipoic Acid in Neuropathy Treatment"

By: Neuropathy Specialists

Date: 04-23-2024

Unraveling the Pharmacokinetic Action of Alpha Lipoic Acid in Neuropathy Treatment

Neuropathy, a condition characterized by nerve damage often resulting in pain, tingling, and numbness, presents a significant challenge in medical management. Among the various treatment modalities available, alpha lipoic acid (ALA) has emerged as a promising therapeutic agent. In this article, we delve into the pharmacokinetic action of ALA in the treatment of neuropathy, shedding light on its mechanisms of action and therapeutic potential.

Understanding Alpha Lipoic Acid (ALA)

Alpha lipoic acid is a naturally occurring compound found in the body, acting as a co-factor for several key enzymes involved in energy metabolism. It possesses potent antioxidant properties, making it a valuable therapeutic agent in combating oxidative stress, which plays a crucial role in the pathogenesis of neuropathy.

Pharmacokinetic Profile of Alpha Lipoic Acid

Absorption

Upon oral administration, ALA is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations reached within 30 minutes to one hour. The absorption of ALA is efficient, with bioavailability estimated to be around 30% to 40%. Food intake may slightly delay absorption but does not significantly affect overall bioavailability.

Distribution

ALA exhibits a wide distribution throughout the body, crossing the blood-brain barrier and entering various tissues, including nerves. Its lipophilic nature allows it to penetrate cell membranes, where it exerts its antioxidant effects directly within cells.

Metabolism

ALA undergoes rapid and extensive metabolism in the liver, primarily through oxidation and conjugation reactions. The major metabolites include dihydrolipoic acid and its acetylated form, which contribute to the overall antioxidant capacity of ALA.

Elimination

After metabolism, ALA and its metabolites are excreted primarily in the urine, with a relatively short half-life of about 30 minutes to one hour. Renal clearance accounts for the majority of ALA elimination, highlighting the importance of kidney function in its disposition.

Mechanisms of Action in Neuropathy Treatment

Antioxidant Activity

One of the primary mechanisms underlying ALA's therapeutic effects in neuropathy is its potent antioxidant activity. By scavenging free radicals and regenerating other antioxidants such as glutathione and vitamins C and E, ALA helps mitigate oxidative stress-induced damage to nerves, thereby alleviating neuropathic symptoms.

Anti-inflammatory Effects

ALA also exerts anti-inflammatory effects by inhibiting pro-inflammatory cytokines and reducing the activation of NF-kB, a key mediator of inflammation. By dampening neuroinflammation, ALA helps attenuate nerve injury and modulate pain signaling pathways in neuropathic conditions.

Neuroprotective Properties

In addition to its antioxidant and anti-inflammatory actions, ALA exhibits direct neuroprotective effects, promoting nerve regeneration and repair. It enhances mitochondrial function, increases nerve growth factor levels, and modulates ion channel activity, contributing to nerve health and function restoration in neuropathic states.

Clinical Efficacy and Safety

Numerous clinical studies have demonstrated the efficacy of ALA in alleviating neuropathic symptoms, including pain, numbness, and tingling, in various etiologies such as diabetic neuropathy and chemotherapy-induced neuropathy. ALA is generally well-tolerated, with few adverse effects reported, primarily gastrointestinal symptoms at high doses.

Conclusion

Alpha lipoic acid holds immense promise as a therapeutic agent in the treatment of neuropathy, owing to its potent antioxidant, anti-inflammatory, and neuroprotective properties. Understanding its pharmacokinetic profile and mechanisms of action provides valuable insights into its therapeutic potential and informs its optimal use in clinical practice. Further research is warranted to elucidate the full spectrum of ALA's effects in neuropathy and optimize treatment strategies for improved patient outcomes. As we continue to unravel the complexities of neuropathic disorders, ALA stands as a beacon of hope in alleviating the burden of neuropathy and restoring nerve health and function.

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Neuropathy Specialists

Neuropathy Specialists has been treating patients with neuropathy since 1999. Our providers and experts have developed an all in one advanced at home treatment for Neuropathy of the hands and feet. With over an 85% success rate, our treatments can not only restore sensation and improve your overall clinical picture, but it is convenient and affordable. All guided by virtual and tele-health professionals that will oversee and guide your treatment ensuring the highest rate of success.

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HOW OUR TREATMENT PROCESS WORKS

We have been treating Neuropathy of the feet and hands since 1999.

At Neuropathy Specialists, all we do is Neuropathy, and we do it well. Our clinic was founded on treating Neuropathy from multiple causes. Treating patients in our clinics using simple yet advanced therapies gave us the idea of sending these therapies home with our patients. If it was successful in the clinic, it would be successful anywhere, even in the comfort of the patients own home. And It was. Now we are dedicated to getting relief to as many patients as possible.

HOW OUR TREATMENT WORKS

VIRTUAL CONSULTATION

All of our patients will undergo a comprehensive virtual consultation to ensure they are a candidate for our at home neuropathy treatment. After your consultation your at home neuropathy kit will be shipped directly to you. You will be guided through the use of the easy at home kit via video tutorials or live virtual support.

KIT ARRIVAL & SET UP

Once the kit has arrived and you have been instructed on its use, you can begin treatment! The treatment is easy, painless, no medications, no adverse side effects. Treatments are performed daily for a period of two weeks. At that time you will meet virtually with one of our providers to evaluate your progress.

START YOUR TREATMENT

Our at home treatment consists of water immersion electrotherapy and photobiomodulation therapy that are safe, FDA Approved, and have over an 85% success rate. Our at home treatment kit also comes with an at home rehab program to help increase circulation and restore lymphatic flow to the feet and lower leg. This advanced combination therapy has helped 1000's to get rid of neuropathy pain and get their life back!

TRACKING YOUR PROGRESS

Our specialized team of healthcare providers will be with you every step along the way. Our team is available 24/7 to help you with questions, set up, treatment performance, and to help track your progress.

George from West Virginia

I had progressive diabetic neuropathy in my feet and it had worked it's way all the way up my calves. After two weeks of using this treatment at home I started to regain the feeling in my legs and feet. It has improved my balance and given me hope for the future! My feet had been numb for two years and my doctors told me that there was nothing that could be done. Thank you!

Jessica from Colorado

I was diagnosed with peripheral neuropathy and it felt like I had a rolled up sock under my toes. It eventually progressed to burning pain constantly in my toes and the balls of my feet. The only option I was given was medication. It helped with the pain but not with the numbness, and it didn't stop it. The burning pain and tingling eventually took over the entire bottom of my feet. After two weeks of the at home treatment the burning pain was gone completely and I was able to get off my medication completely!

FAQS

How does this treatment work?

Our treatment program uses a combination of the 3 most studied and successful treatments available. These therapies have been shown to be the most successful with Diabetic Neuropathy, Peripheral Neuropathy, and Chemotherapy Induced Peripheral Neuropathy. We have seen truly amazing results in many different types of neuropathy patients. Our passion is helping those with neuropathy using the latest and most effective treatments, all from the comfort of your own home, and we want it to be affordable.

First we use water immersion electrotherapy and neuronal stimulation to get your damaged nerves to fire again. Using water immersion ensures that every neuron and nerve in the foot and lower leg are activated. Patients with severe neuropathy symptoms may feel little to no sensation for the first few treatments, but gradually sensation will return as the damaged nerves begin to rebridge and repair. Most patients will feel the tingling and electrical impulses immediately. By the second week of daily treatments 85% of patients report seeing significant improvement in their neuropathy symptoms.

Second the feet and lower leg are wrapped in a power Photobiomodulation unit which delivers multiple wavelengths of healing infrared light and this stimulates mitochondria activation in your cells. Mitochondria are your cells power plants, they produce energy to help your cells conduct vital activities such as repair. These wavelengths also stimulate your nerves regrow and repair damage neuronal connections, and to regrow the microvasculature and blood vessels that feed your nerves and tissues.

Third, Alpha Lipoic Acid is used which helps to repair the myelin sheath surrounding the nerves and increases nerve conductivity. Some research studies have suggested that Alpha Lipoic Acid be used in place of other common prescription medications for relief of neuropathy pain.

The combination of these three therapies together is what produces the long term healing effects that we have seen with 1000's of our patients. Our goal is to heal the damaged nerves and restore vital circulation.

All guided by our live virtual tele-health consultations with our Neuropathy Experts. Our support team is here to help 24/7 with technical questions or anything you need.

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Beware of Common Neuropathy Scams!

In the world of neuropathy scammers are everywhere. We have built our business and our reputation on providing real relief to our patients at affordable prices.

Similar treatment programs to ours can be found in many neuropathy clinics across the United States. However, these clinics charge anywhere from $2,500 to $5,000 for the exact same treatments we provide. The equipment is the same, and yes those patients will see results as well, but the inflated cost is taking huge advantage of those patients that are in pain and looking for relief.

Many people on social media will tout Alpha Lipoic Acid as "all" you need to "cure" neuropathy. We too wish it were that easy, and yes Alpha Lipoic Acid can help drastically but it alone can not cure neuropathy. Most of these social media doctors are actually selling their own brand of ALA, and will make wild claims as to its effectiveness. ALA is crucial to our treatment program, but it is not the only tool in the tool box.

Beware the clinics and doctors selling the "Rebuilder", The Rebuilder is a brand of electrotherapy device that is insanely expensive and does nothing more magical than any other electrotherapy device. In fact it is the exact same technology we use in our electrotherapy device. Many clinics charge an average of $5,000.00 for their "neuropathy program" with the rebuilder as the star of the show. Our electrotherapy device costs us about $50.00, and our entire program is only $399.00. Hardly seems fair to charge $5,000 for the same thing? That's what we thought.

Many patients that come to us are confused because their doctor put them on medication for their neuropathy, and their neuropathy is not getting better. That is because these medications do not treat neuropathy, reverse it, or even help it in the littlest bit. Instead these medications deaden the neuronal impulses of the already damaged nerves, causing them to be "quieter." This quieting of the nerves only helps to speed up their decline and already decreased functionality, in fact worsening and speeding up the neuropathy. This is hardly ever explained accurately to patients. Instead, they are typically told that nothing more can be done. That is not the case.

In short, there is no cure for neuropathy. Especially not for $29.99 and certainly not for $5,000.... Our clinically proven treatments are not a cure, but they repair and regenerate the damage done to the nerves. This reverses neuropathy but in most cases the underlying cause is still present, and constantly attacking the nerves. Our treatment repairs this damage and then fights the causative agents to prevent further and future damage. In the case of diabetic neuropathy, we can't cure the diabetes of the patient, so the damage from diabetes will still try and attack the nerves, our treatments will repair the damage, relieve the patients symptoms, and then continued treatment will ensure the damage can not accumulate to a point where it causes more symptoms. Effectively managing the condition. The same is true for many other types of peripheral neuropathy. In some cases like Chemotherapy Induced Peripheral Neuropathy, the damage can be repaired and the nerves regenerated, and so long as the patient is not undergoing chemotherapy, then yes that case can be effectively cured.

We strive to offer patients transparency, effective treatment, and affordability. We have been treating neuropathy since 1999 and we have consistently improved our therapies, decreased our prices, been an industry leader in both clinical excellent and business ethics. Don't be fooled by the many on social media preaching cures. Even our treatment is not 100% effective in all patients. We have over an 85% success rate with our patients, and we don't stop until we ensure every patient gets the relief they are looking for.

Do I need a prescription for this treatment?

No prescription is required for this at home treatment kit. Our neuropathy experts are licensed providers and will work with you and your current providers to ensure you receive the latest in neuropathy care.

Is the treatment FDA cleared?

Yes. These forms of treatment have been cleared by the FDA for treatment of peripheral neuropathy. Though these devices are cleared by the FDA for use. The FDA has not evaluated their efficacy in the treatment of neuropathy and the FDA does not endorse or evaluate the statements made about the effectiveness of their treatment, only that they are approved to treat those specific conditions.

Does insurance cover this treatment?

Unfortunately insurance does not directly cover the purchase of these treatments. However, you can submit a copy of your receipt to your insurance company for reimbursement or have it applied to your deductible. These devices are also HSA and FSA eligible purchases.

Does medicare or medicaid cover this treatment?

Unfortunately these devices are not covered by medicare or medicaid.

Can I use my HSA or FSA to purchase this?

Absolutely! These devices are HSA and FSA eligible. If you require assistance with submitting these purchases for reimbursement just contact our support team!

Can I use this treatment with my other current neuropathy treatments?

Absolutely. These advanced at home treatments can not interfere with any other neuropathy treatments and can absolutely be performed simultaneously with other treatments. These treatments can only help to improve the results of other combined treatments. These treatments will not effect any current neuropathy medications you may be taking.

Will I be able to get off my medication if this treatment is successful?

Our goal is to help you safely get off your medications for neuropathy. This treatment is designed to actually regrow your nerves and the blood vessels that feed them. Restoring circulation and feeling to the damaged areas. Our goal is to help you safely get off your medications for neuropathy. We will work with you and your prescribing physician when the time is right to decrease and hopefully eventually the use of these medications.